Sentence examples for substantial pathogenic role from inspiring English sources

Although some studies have suggested a substantial pathogenic role for these viruses (3 ), controversy still exists (4 ).

Substantial evidence has been garnered for the pathogenic role of CD40 ligand (CD40L), a member of the TNF family [ 21- 26].

At this point we cannot tell if the three informative AGEs play a causative role in DN progression or reflect turnover of increased tissue stores of these AGEs, but considering that there is substantial evidence that AGEs can play a pathogenic role in vascular damage (32– 34), the former is possible.

Evidence is presented for a pathogenic role of the agrin/neurotrypsin system in a substantial subset of sarcopenia patients.

Similar to our finding in mice, Noster et al. found that GM-CSF-producing TH cells represent a substantial population in the cerebrospinal fluid of MS patients, suggesting a pathogenic role of these cells in neuroinflammation.

Epigenetics plays a critical pathogenic role in the development of complex eye diseases including myopia13.

Yoo, S. A. et al. A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.

A pathogenic role of caspase cleavage has also been implicated in other neurodegenerative disorders.

Leukocytes play an important pathogenic role in ischaemia-reperfusion injury.

Type I interferon (IFN-I) has been shown to play a pathogenic role in this disease.

Evidence for a pathogenic role of antibodies and immune complexes is missing.