In the study, mutations of p53 gene and K-ras gene codon 12, and promoter hypermethylation status of p16, RASSF1A, and APC1A gene, were also examined because these gene alterations had substantial role in pathogenesis of NSCLC and whether or not they correlated to EGFR mutations could help to further clarify the importance of EGFR mutations on pathogenesis of NSCLC.
Some authors [ 5, 15, 27, 32, 38– 41] suggest that inflammation plays a substantial role in the pathogenesis of POCD.
These cytokines play a substantial role in the pathogenesis of Crohn's disease, and anti-TNFα therapy is often used to treat patients with this disease.
Furthermore, notching and/or a thick cement mantle or other findings linked with inaccurate surgical technique do not seem to play any substantial role in the pathogenesis of these fractures.
Furthermore, based on our results as well as those from other investigators we think that CCL3 and CCL4 do not have a substantial role in the pathogenesis of pulmonary sarcoidosis.
Therefore, we suggested that if the femoral remnant was viable and did not display any pathological changes that might have caused its weakening, then biomechanical factors played a substantial role in the pathogenesis of those fractures.
One can only speculate whether such propagation of superficial necrobiosis into deeper soft tissue also plays a substantial role in the pathogenesis of the anterior localized soft tissue granulomatous pseudotumors (Pandit et al. 2008a, b) following M-o-M hip arthroplasty; however, the histopathological findings appear to be essentially identical (Fujishiro et al. 2011).
Nowadays, substantial evidence indicates that the pathogenesis of many autoimmune diseases is related to overproduction of hIFNγ.
Still, this donor variability highlights a substantial potential impact on the pathogenesis of M. tuberculosis that has to be considered.
Understanding the functional significance of G-quadruplex binding in vivo may therefore be of substantial importance in elucidating the molecular pathogenesis of Fragile X syndrome.
