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However, it is important to keep in mind that the need for a decision support infrastructure represents just one of several substantial obstacles that must be overcome before genomic and personalized medicine can become routine components of clinical care.
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However, the written style of scientific papers represents a substantial obstacle that needs to be overcome for such 'automated' methods to be successful.
Still, Mr. Weiner faces substantial obstacles, including that several of his former aides have now signed onto other mayoral campaigns.
He knows the personal histories and anecdotes of his field, the obstacles that had to be overcome to reach our present state of knowledge, and the substantial uncertainties that dominate the frontiers of research.
Given the high level of satisfaction with the interpreters that were assigned to such missions, language did not appear to pose a substantial obstacle to STMMs that had translators available.
Those who favor military action are again making the threat appear closer than it is by minimizing the substantial technological and engineering obstacles that Iran must overcome to be able to enrich uranium and manufacture a weapon.
The alarming fact is that millions of students across the country attend school in dilapidated, obsolete and/or unhealthy facilities that pose substantial obstacles to learning and overall wellbeing.
At this point, I'll just state that although I agree completely with the Reviewers that there are substantial obstacles to the introduction of the Scans into clinical practice, I also feel that the obstacles are definitely surmountable, and that the time to begin working on these problems is now.
Professor Thomas said the concept of a Koran that predates Mohamed would require "a radical revision of Islamic history", adding: "I think there are substantial obstacles in the way of that".
"I hope there will be no premature, self-congratulatory statements suggesting the crisis is over, for we all know that there are still substantial obstacles to overcome.
"For we all know that there are still substantial obstacles to overcome: the growth figures remain low and the tentative signs of growth are still fragile".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com