Law-abiding aliens might wish to return to their home country, for instance, but the strained relationship caused by the difficult repatriation talks might prove to be a substantial obstacle for these aliens as well.
"This poses a substantial obstacle for business in China, especially when considered alongside the concerns over I.P.R. enforcement and de facto technology transfer requirements," the chamber said, referring to weak enforcement of intellectual property rights.
This would appear to be a substantial obstacle for obtaining care in non-governmental facilities.
It is pointed out that the neutral current sheet of the IMF does not represent a substantial obstacle for energetic charged particles.
In real simultaneous applications, like event-related fMRI study, artifacts induced by MRI events on EEG traces represent a substantial obstacle for a right analysis.
This is said to be the way more mainstream users want to consume music, which is convenient given the cheaper rates charged by the music industry for a service deemed to be Internet radio, while We7 believes that offline playback removes a substantial obstacle for this type of consumption to move to mobile.
The observation that immunodeficient mice and immunocompetent mice were equally susceptible to chemically induced tumour formation was a substantial obstacle for Burnet and Thomas' immunosurveillance hypothesis to overcome.
CD8+ T cell tolerance, although essential for preventing autoimmunity, poses substantial obstacles to eliciting immune responses to tumor antigens, which are generally overexpressed normal proteins.
That may well be the case for Mr. McCain too, and he faces substantial obstacles.
Nonetheless, there remain substantial obstacles to the more general use of phylogeny-based inference for whole-genome analysis in eukaryotes.
