Under less harsh conditions, in which some proteins can be tricked into being unfolded in the absence of denaturant (for example by mutating the sequence or changing the pH), the unfolded state has been shown to contain significant native-like interactions formed in concert with substantial numbers of both native and non-native side chain contacts [16,17].
Genetic interactions with nonmigratory O. mykiss, the use of substantial numbers of primarily native broodstock with an approximate 1 1 male-to-female ratio, and/or poor survival and reproductive success of hatchery fish may have minimized potential genetic changes.
For example, because non-native interactions are not considered in simple Gö-type models, their presence raises questions about how well such potentials can describe the energy landscapes of proteins that fold via the formation of substantial numbers of non-native contacts.
Furthermore, NUP98-HOXA9 aboutteightoutimesht timoremore genes than HOXA9, with a substantial number of them regulated by the fusion but not by the native HOXA9 protein, intriguingly including the Mef2c gene.
If a substantial number of low energy docked poses cluster in a narrow vicinity of the native structure of the dimer, then one can assume that there is a well-defined free energy well around the native state, which makes the interaction stable.
At first, Botaneiates lacked any substantial number of troops to oppose Bryennios, who in the meantime had consolidated his control over his native Thrace, effectively isolating the capital from the remaining imperial territory in the Balkans.
Structural studies were revealing that a substantial number of proteins or segments of proteins in complex organisms are intrinsically disordered, lacking a stable well-defined tertiary structure in their native state [ 7, 8].
A substantial number of fatalities occurred in businesses.
Still, a substantial number of Americans are not convinced.
He added that a "substantial number of those people" would probably be "members of the A.C.S".
