Even if--in a substantial number of clusters--the difference between the largest and the shortest sequences was important, we were still assured that the size of the consensus sequence was the largest possible for each cluster.
Upon detailed inspection of the results we found that while some of the modules extracted using this technique are highly functionally homogeneous (by construction), this comes at the cost of a substantial number of spurious clusters.
Conversely, very few promoters (induced 0.1%%, non-induced 0.4 %) were located distal to non-induced DHSSs, while a substantial number of TSS clusters (induced 11%%, non-induced 13%%) were located distal to induced DHSSs.
Some preliminary clusters should be merged if they have substantial number of interconnections to improve clusters' quality.
The only exceptions known so far are squamate reptiles, with the lizard Anolis carolinensis as a striking example of having accumulated a substantial number of retrotransposons in its Hox clusters, resulting in considerably larger cluster sizes [ 15, 16].
Because of the sequence divergence between Spr and B6, the substantial number of downregulated probes and downregulated clusters might reflect this divergence and not the decreased expression.
If a substantial number of low energy docked poses cluster in a narrow vicinity of the native structure of the dimer, then one can assume that there is a well-defined free energy well around the native state, which makes the interaction stable.
However, movement patterns of cluster 1 were not associated with clusters 3 and 4. A substantial number of fish (10 individuals) also died directly after showing the symptoms associated with cluster 1 but not clusters 3 and 4.
In addition, a substantial number of persistent and recurrent SNPs, and clusters of co-occurring SNPs, implicate a broad range of pathways and functions that likely provide some growth advantage in the presence of the complex selective pressures found in the host.
The discovery of two old open clusters with a substantial number of stars rotating in alignment with each other could represent an imprint of the original angular momentum of the parent molecular cloud from which the stars formed.
