"substantial novelty" is correct and usable in written English.
You can use it to describe something that is completely new and different compared to what has come before or to describe something that is of considerable significance or importance. For example, "The new software created by the tech company brought substantial novelty to the industry."
The sole concert that broke with that notion, presented at Avery Fisher Hall on Saturday night, included nothing by Mr. Adams; the whole evening was given over to Bruckner's towering Symphony No. 8. Yet here, too, was a substantial novelty: Mr. Welser-Möst chose the original 1887 version of the score, as it existed before Bruckner made substantial changes.
In both cases, we believe there to be substantial novelty and significance over and above what we have published previously.
We believe that there is substantial novelty in this work from the point of view of testing the idea, firm in the literature, that Polycomb bivalency is a good proxy for identifying poised genes in all lineages in pluripotent embryonic stem cells, and that PRC2 is required for poising of neuronal genes regulated by REST.
Instead, given its substantial novelties, our algorithm can be used in addition to other algorithms in order to provide complementary information.
To be fair however, both substantial utility and novelty can be found in the manuscript, pursuant to the fact that it represents the first study of data variability in the Illumina bead-based microarrays.
Our data suggest that CatSper1-4 hacquiredirevolutionaryary novelties through substantial altered functional constraints after possible ancestral replication.
Recent work also suggests that LTR retrotransposons (and other major classes of transposable elements) may not exclusively represent selfish or junk DNA as previously supposed [ 20, 21] but that, on occasion, transposable elements may have indeed played a more substantial role in generating evolutionary novelty [ 22- 33].
Extensive, long-term stigma-reduction campaigns will require substantial toolkits of interventions to maintain novelty and momentum.
Second, MRI was subject to substantial uncertainty due to the technological novelty of the innovation.
We hope you find that our new paper has made substantial improvement, and that the conceptual novelty of our theoretical work, inspired and verified by our novel experimental findings, is now more clearly accentuated.
Retroposition, an RNA-intermediated copy mechanism, could shape genomes widely in eukaryotes, and in particular plays a substantial role in evolution of functional novelties [ 1].
