This is called strong normalization.
This is not a substantial issue for linear normalization, which is mostly driven by a large contrast change at the outside boundary of the brain, but the blurred internal structures could easily confuse high-dimensional non-linear registration [21].
Data normalization has substantial impact on the performance of statistical methods for DE analysis of sequence count data.
These results suggest data normalization has substantial impacts on the performance of DE tests in terms of type I error and FDR.
Both PTL and VSN appear to provide substantial improvement over the normalization utilized by Xia et al. (2007) (fig. 1 and supplementary fig. 1, Supplementary Material online).
Based on our data, we estimated that to achieve a reasonable completeness (≥ 75%) of the three quarters of most abundant (after normalization) transcripts, substantial additional sequencing effort may be needed, rendering the two-step strategy problematic.
As drugs are registered in the FAERS by arbitrary names, e.g. trade names and abbreviations, and may even contain typographical errors, the lack of drug normalization introduces substantial barriers for data integration in signal detection.
About 80% of oligos (30,162 out of 36,797 unigenes) turned out to be specific for one Torvum unigene, while 15% oligos were specific for 1 3 unigenes, (Additional file 2) indicating efficient normalization and substantial lack of redundancy in the Torvum unigene set.
Clear and significant antitumor activity was demonstrated with VDC-1101 by clinicopathologic assessment of serum paraproteins, bone marrow cytology, and a sensitive PCR-based assay for detecting clonal immunoglobulin gene rearrangement, as well as normalization or substantial improvement in a variety of MM-associated clinicopathologic abnormalities.
In the present study, we found that parameter normalization resulted in substantial improvements performance metrics, as reported above.
