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All these aspects provide substantial new challenges for modelling and computation of this basic genetic process which itself combines different scales and levels of complexity.
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So if you stay a company for a long time, make sure you accomplish something substantial and then take on demonstrably new challenges.
However, while historical practice among ICUs appears to have been to restrict visitation and we have seen concurrent substantial improvements in short-term mortality, new challenges in critical care have arisen.
Treatment toxicity on re-challenge was acceptable; no substantial new toxicity or increased severity of prior toxicity was noted.
Substantial efforts have been made to meet the new challenges.
Substantial new or increased severity of toxicities was not reported during re-challenge.
New challenges, new things.
"New technology brings new challenges".
Be open to new challenges.
Here, life presented new challenges.
After Rocky new challenges await.
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