The phrase "substantial negative effects" is correct and can be used in written English.
It is typically used to describe the significant or considerable consequences or impacts of a particular action or event. Example: The government's decision to cut funding for education has had substantial negative effects on students, teachers, and the overall quality of education in the country.
difference between the two groups is large enough to have substantial negative effects on the economy and on American society".
By paying taxes and buying new products we sustain a market economy that has substantial negative effects on the poor.
All this could have "substantial negative effects on online economies and social cultures across Africa," it says.
While the effect on employment quality is not available, the authors suggest that the complete withdrawal of benefits may have had substantial negative effects on employment quality or labor force participation.
The casting thickness, non-woven fabric type and casting speed were found to have substantial negative effects on the pure water flux values, and were identified as the significant factors determining the membrane pure water flux.
However, some of the patients may suffer from long-term or even permanent disability, with significant medical and medico-legal consequences (Givol et al., 2011; Givol et al., 2010) and substantial negative effects on their quality of life (Pogrel, 2017; Rosen, 2014; Pogrel, 2007; Pogrel et al., 2011; Juodzbalys et al., 2011; Seddon, 1942; Leung et al., 2012).
We did not find that this decision support package improved satisfaction with treatment; it may have had a substantial negative effect on clinical outcome, and is very unlikely to prove cost-effective.
The employees would face a corresponding 20 percent cut in pay, which Mr. Panetta said would have a substantial negative effect on the economy.
"The results from our randomised experiment suggest that computer devices have a substantial negative effect on academic performance," the researchers concluded, suggesting that the distraction of an electronic device complete with internet access outweighed their use for note-taking or research during lessons.
"Given the large volume of traffic to our Web site and the importance of the placement and display of results of a user's search, similar actions in the future could have a substantial negative effect on our business and results of operations," the company warned in its latest filing.
But dung is used as source of manure, and using it for fuel can have substantial negative effect on soil fertility.
