Sentence examples for substantial modifications are from inspiring English sources

The fundamental assumptions in the GDC have withstood the test of time and no substantial modifications are required.

Substantial modifications are proposed to optimize the algorithm, while the effects of refractive propagation paths are considered.

No substantial modifications were introduced by subsequent Treaties until the major changes brought by the Treaty of Lisbon.

Moreover, substantial modification was seen in the hydrophobicity and surface roughness.

Subsequently, no substantial modification was seen of the HRs for RFS in BRCA1-likeCGH (adjusted HR: 0.17, 95% CI 0.05 0.60; Figure 2F and Table 4) and non-BRCA1-likeCGH patients (adjusted HR: 0.88, 95% CI 0.30 2.57; Figure 2E and Table 4).

However substantial modifications have been made to the notation system from the introduction of new symbols to changes in the aesthetics of the scheme and pathway syntax in order to achieve our original objectives.

Substantial structural modifications were necessary to engineer this antigen, with the 2F5 epitope replacing a helix in the native scaffold and with 15% of the native scaffold sequence being modified in the design stage.

Between 1874 and 1878 work was done at a cost of £1600 and in 1898 the lighting was converted from gas to electric, substantial internal modifications were carried out and repairs made to the clock tower which cost around £2200.

The chapterhouse, which had been attached to the choir through a short vaulted vestry, required substantial modifications and was now provided with a vaulted roof supported by a single pillar (Figs. 13 & 14).

Further modifications are almost inevitable.

First, not all loan modifications are equal.