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In summary, the identification of a potentially new functional SNP with a substantial minor allele frequency within alternative exons of OPRM1 is of considerable importance to the field of pain genetics.
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There were, however, a number of substantial and minor concerns that need to be dealt with before this paper would be suitable for publication.
I have argued (Jaworska unpublished) that when the interests of the earlier person are relatively minor, substantial interests of the current nonperson ought to trump.
Consequently, eCall (equipped with accurate location information such as Global Positioning System, GPS) is expected to have the most substantial effects on minor rural roads, at night-time, and in off-peak traffic.
During the course of our NMR experiments on the C22V variant of FKBP12, we noted a substantial set of minor peaks at approximately 15% of the intensities for the major amide resonances in the standard H-N 2D correlation spectrum.
Although substantial differences in minor allele frequency were observed between each sensitive and tolerant pair, the frequency shift between KC and ER was in the direction opposite of the other three pairings.
Patients were also asked to state their previous efforts to change their lifestyle (none, minor, substantial, major change) with physical exercise and diet, with the aim of improving their health.
There is no statutory definition of "impairment" and the meaning of "substantial" is "more than minor or trivial".
Grieg was celebrated with his more substantial Ballade in G minor, which belies its name as a large-scale set of variations on a Norwegian folk song.
The law also details "civil recovery statutes," by which retailers may use the threat of a civil lawsuit to recover substantial settlements for even minor thievery.
From the different distributions it is seen that electrostatic effects are not substantial for Pt(100), minor but significant for Pt(110) and quite important for Pt(111).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com