Sentence examples for substantial methodological limitations from inspiring English sources

All trials had substantial methodological limitations.

All trials had one or more substantial methodological limitations.

Despite this heterogeneity and the substantial methodological limitations, our review suggested that nurse-led care is associated with higher patient satisfaction, lowered overall mortality and lowered hospital admissions.

The use of staples for closing hip or knee surgery wounds after orthopaedic procedures cannot be recommended, though the evidence comes from studies with substantial methodological limitations.

Studies using gastrokinetic drugs to improve glycemic control in type 1 diabetic patients have substantial methodological limitations and have yielded inconsistent observations.

Many previous nonrandomized studies, however, have suffered from substantial methodological limitations, lacking adjustment for many potential confounders, active controls, incident-user designs, uniform follow-up, or intent-to-treat designs [ 10].

Both studies had significant methodological limitations.

Third, substantial methodological differences between them limit their comparability.

A second limitation is the substantial methodological and statistical heterogeneity seen in the selected studies.

They found a wide range of methodologies, settings and outcome measures, and described considerable methodological limitations, but concluded that "the impact of headache in children and adolescents was substantial".

Econometric studies are subject to certain methodological limitations but they suggest that the economic benefits are very substantial.