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Third, substantial methodological differences between them limit their comparability.
It can be assumed that these inconsistencies of GM and WM abnormalities in previous studies can mainly be attributed either to substantial methodological differences or to the inclusion of only small and heterogeneous samples.
Librett and Perrone [ 8] suggest that because of the substantial methodological differences between qualitative work and what they describe as the 'positivistic' frameworks of ethics, ethnographic research should be examined under a different review process to quantitative approaches.
However, there are substantial methodological differences between the eight studies that were analysed, starting with the nature of the data source (i.e. the patient data came from stroke units, rehabilitation units, population-based studies, and stroke registers).
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Else, there could be a substantial methodological difference between the work of Ren et al. (2006) and the studies that report the C↑E trend, especially considering that the study of Ren et al. is unique in using the massively parallel signature sequencing (MPSS) technology (Brenner, Johnson, et al. 2000; Brenner, Williams, et al. 2000) to measure expression levels.
Caution is recommended when interpreting and comparing results of different studies, as methodological differences and challenges are substantial (cf. introduction).
These differences are quite substantial and may in part be due to methodological differences.
While there are methodological differences between these studies it seems likely that there are substantial differences in consumption of soft drink both between populations within Australia and between Australia and other countries.
According to these methodological differences, CH-plot analysis is predisposed to discriminate proteins with substantial amounts of extended disorder (random coils and pre-molten globules) from proteins with globular conformations (molten globule-like and rigid well-structured proteins).
Substantial methodological risks of bias existed across all studies in our animal sample, although we could not detect differences in risks of bias between the non-industry and industry sponsored studies.
There was a substantial discrepancy in the outcomes across these studies, most likely due to study size, disparate outcome definitions, and methodological differences.
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