Exact(1)
Else, there could be a substantial methodological difference between the work of Ren et al. (2006) and the studies that report the C↑E trend, especially considering that the study of Ren et al. is unique in using the massively parallel signature sequencing (MPSS) technology (Brenner, Johnson, et al. 2000; Brenner, Williams, et al. 2000) to measure expression levels.
Similar(59)
Third, substantial methodological differences between them limit their comparability.
It can be assumed that these inconsistencies of GM and WM abnormalities in previous studies can mainly be attributed either to substantial methodological differences or to the inclusion of only small and heterogeneous samples.
Librett and Perrone [ 8] suggest that because of the substantial methodological differences between qualitative work and what they describe as the 'positivistic' frameworks of ethics, ethnographic research should be examined under a different review process to quantitative approaches.
However, there are substantial methodological differences between the eight studies that were analysed, starting with the nature of the data source (i.e. the patient data came from stroke units, rehabilitation units, population-based studies, and stroke registers).
Substantial methodological risks of bias existed across all studies in our animal sample, although we could not detect differences in risks of bias between the non-industry and industry sponsored studies.
A second limitation is the substantial methodological and statistical heterogeneity seen in the selected studies.
Nevertheless, we expect that the use of smartphones will offer a substantial methodological improvement on current time use research.
Recently, a systematic review also reported that substantial methodological and clinical heterogeneity was found among the studies in this issue.
A substantial methodological decision in this process is to work out concept systems separately for each language to be standardized.
All trials had substantial methodological limitations.
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