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Most currently available structural variant callers employ multiple passes through the entire input file, requiring substantial memory and computation time.
Also, the size of sequencing datasets produced is often very large, and therefore requires substantial memory and long computing times, even for the very efficient De Bruijn graph-based assemblers [ 8- 10].
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The design of a parallel version for MSA with A-Star is subject to challenges such as irregular dependency pattern and substantial memory requirements.
BUCKy-pop strictly runs in serial, using a Bayesian Markov Chain Monte Carlo (MCMC) technique, which can take a long time and substantial memory to reach convergence.
Therefore, this method does not require any training, but its testing stage includes high computational load and a substantial memory footprint.
Still, these method are also not suitable for mobile environment since they require several hundreds of parallel training sentences and/or very high computational load during conversion and a substantial memory footprint.
But by seven weeks, the post-stroke mice had developed substantial memory deficits.
(The therapy is perhaps most famously depicted in the book and film One Flew Over the Cuckoo's Nest). The severe side effects – such as substantial memory loss – mean that it is often considered a last resort for the most severe cases.
Considering the substantial memory usage of the hash table using structural database to reduce memory requirement becomes markedly relevant.
RAPSearch, however, requires a substantial memory footprint to identify alignment seeds, due to its use of a suffix array data structure.
However, because RAPSearch uses a suffix array to index the database sequences for seed identification, it uses substantial memory for searches in large databases.
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