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The phrase "substantial margin for" is correct and usable in written English.
It can be used when discussing the amount of leeway or flexibility available in a situation, often in contexts like finance, planning, or decision-making. Example: "The company has a substantial margin for error in its budget, allowing for unexpected expenses."
Exact(2)
Mr. Dukakis, a Democrat, led Governor Bush's father by a substantial margin for months but faltered after the conventions.
Between 2005 and 2011, injury rates in the cycle hire zone were generally highest by a substantial margin for motorcycling, followed by cycling, walking, car or van, and bus, and finally train, underground, and taxi (table 4).
Similar(55)
But a Republican Party that rejects Donald Trump after he had led the entire field by substantial margins for almost a year could stimulate a seismic political revolt leading to a third party campaign.
Even allowing for the substantial margin of error in the monthly figures close to a hundred thousand this looks like a notable fall-off.
b) For most of the compounds, there is a substantial margin of safety between the current permissible exposure levels and levels that would be expected to cause overt signs of neurotoxicity in humans.
The substantial margin of passage in both houses obscured visceral disagreements over philosophy and ideology.
Indeed, Americans at the time supported Roe by a substantial margin of 52percentto44percentcent.
A poll conducted online for Channel Four television showed the Conservatives leading his Labor Party by a substantial margin, and another online poll, for The Times of London, showed that confidence in Mr. Brown's competence as prime minister had fallen.
I reckon a quick straw poll of Sweden's neighbours would see it voted the world's självgodaste country by a substantial margin, and I'd vote for that, too.
Tall and rangy, with a pugnacious style as she crouches over her bike in the sprint, James enjoyed flawless progress to the final, qualifying fastest on Friday with a substantial margin off her personal best for the flying 200m time trial, then enjoying a bye to round two.
That - by a substantial margin - is the best score for any police force in England and Wales.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com