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Hence, one can coarse-grain the system of choice as long as one does not miss substantial lower level effects.
As soon as direct links spanning more than one layer of complexity start to interfere, hierarchical reduction is limited by potential loss of substantial lower level effects).
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They concluded that only small to moderate differences were found on measures for psychological well-being and that the majority of the visually impaired people did not have lower levels of well-being, although substantial lower levels were found among individuals with severe vision loss and age-related macular degeneration (AMD).
In a cluster of 10 subjects with the most severe disease there was a substantial and significantly lower level of anti-P.
However, we found that a substantial proportion of the lower level facilities (health centers) were not initiating patients on the preferred first line ARV regimen.
(And yes, the feds have an influence: the Recovery Act contained substantial aid to lower levels of government, which should have been continued).
Particularly in the Late Devonian, extinction events may relate to periods of abrupt cooling associated with the development of glaciers and the substantial lowering of sea level.
The individual plots of IgG for 25 longitudinal observations over 11 years showed substantial dynamics: the lower levels seemed to increase and the higher to decrease (Additional file 1).
Numbers of bacteria were lowered for pathogenic species since preliminary experiments had shown that cell lines were damaged following exposure to higher cell numbers: whilst 10 lactobacilli are representative of numbers found in the colon, pathogenic bacteria inflict substantial infection at lower levels.
However, the activation, albeit at a lower level, of a substantial fraction of defence-like genes in WT nodules ("exo1" subgroup) raises interesting questions regarding their role during normal nodule development, discussed below in the section on regulator genes.
In our limited geographical area it is possible that the genetic diversity is at a lower level even though we found substantial diversity using AFLP and Rep-PCR.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com