Sentence examples for substantial loss of function from inspiring English sources

This may result in a markedly increased morbidity and substantial loss of function, as well as debilitating cosmesis rather than in a complete termination of life, as is the goal.

In general the effect of mutating individual residues is variable, ranging from a substantial loss of function, such as the BB loop proline residue, to partial or no loss of signalling.

RA is characterized by inflammatory synovitis and destruction of cartilage and bone, which usually leads to substantial loss of function and mobility.

This result is remarkable because previous mutagenesis of Q823 revealed a broad spectrum of activity, ranging from substantial loss of function (Q823-C or I) to superactivity (Q823-D or E; [ 20]).

Even if AOX can restore redox balance, mitigate mitochondrial reactive oxygen species (ROS) production (6– 9) and limit systemic lactic acidosis (6), tissues that depend on such substrates may still suffer a substantial loss of function that AOX cannot correct.

The ability of each ZRT1 allele to rescue the ZRT1 deletion phenotypes indicates that none of the 38 amino acid polymorphisms that distinguish these three ZRT1 alleles caused a substantial loss of function as measured by growth or fermentation rate under the conditions assayed.

Mutation of these clusters in combination appears to render substantial loss-of-function with regard to β-arrestin interaction strength, despite no apparent reduction in cell surface expression as determined by assessment of proximity to the Kras cell surface marker.

RA affects approximately 1 % of the world population and, if inadequately treated, leads to pain, swelling, and progressive destruction of joints, with resulting disability, substantial loss of functioning, and mobility or work incapacity, decrease in quality of life, or reduction of life expectancy [ 1– 3].

Although appropriate for large comparative and epidemiological studies, the AKIN classification may not be an accurate tool to assess a particular drug-related nephrotoxic effect in critically ill patients, because a rise in creatinine concentration occurs only after substantial loss of renal function.

Combining the two sets of mutations, however, appeared to cause the most substantial loss of Vpu function, suggesting a potentially parallel nature for these pathways.

This result indicates that under the conditions tested, none of the nonsynonymous differences among the three alleles caused a substantial loss of ZRT1 function.