Our study also reveals that the cause of JBTS has been elucidated in the great majority of our FC subjects (33/35 [94%] families), even though JBTS shows substantial locus and allelic heterogeneity in this population.
A proliferation of recent genetic investigations and reviews suggest that multiple rare allelic and/or structural variants and therefore an architecture characterized by substantial locus and allelic heterogeneity may explain a substantial proportion of susceptibility to major neuropsychiatric disorders [3], [4], [79], [82], [83], [84], [85].
The chromosomal regions of substantial SD loci found in this study were compared to the regions with quantitative trait loci (QTLs) underlying hybrid sterility/fertility and gametophyte genes reported in previous studies on rice.
More generally, we found substantial among-locus variation in cline estimates (Fig. 3, Additional file 4: Table S1), which may also stem from drift, since outliers were not the same between transects, although one cannot rule out differential selection acting on individual markers, especially given that the ecological context, and thus the nature of selection, may differ between transects.
Thus, results of both ChIP-seq and conventional ChIP followed by quantitative polymerase chain reaction at select loci indicate substantial loss of Abf1 binding from both memory effect and transcriptionally responsive targets, with the loss being slightly greater from responsive gene promoters.
At the nLTRS locus, substantial differentiation between M. rhizophorae and M. eastropacensis (see Figure 1B) suggested a much higher rate than estimation based on divergence in Chthamalus alone.
Nevertheless, the interesting findings from these meta-analyses is complementary to recently published gene-based approach that was used to analyze primary GWAS data in ways that allow for substantial allelic and locus heterogeneities [ 25- 27].
Substantial differences in locus order were observed on the current sequence assembly, when the position of sequence contigs is arranged in strong contrast to the placement of the corresponding loci by RH mapping (e.g., for MLR1 and HACP-G on NW_931678.1; LPHN3 on NW_931658.1; IOBT450 and KDR on NW_931714.1; PF4 and CXL1 on NW_931715.1).
This new RH map with a total of 234 loci including 115 genes and ESTs displays a substantial increase in loci density compared to existing physical BTA6 maps.
As predicted, we find a substantial association between locus-specific divergence between allopatric populations and locus-specific introgression in admixed populations.
A locus-by-locus pairwise Fst comparison between the different tomato classes indicated the presence of substantial variation among loci.
