Thus, large metropolitan areas will contain substantial "local populations that are either functionally unnecessary or socially disruptive" [ 147](p. 404).
To be fair, Leicester are not alone: fans of many other teams - from Aston Villa to Blackburn Rovers to Huddersfield Town, where there are also substantial local Asian populations – tell me they don't see many Asians at their grounds.
In 722 BCE, the northern kingdom was conquered by the Assyrians, who exiled a substantial portion of the population, and in 597 the Babylonian ruler Nebuchadnezzar II asserted control over Judah, where ten years later he would lay siege to Jerusalem, destroy the Temple of Solomon and exile a substantial portion of the local population to Babylon ((van de Mieroop 2007): 251 and 276).
As screening progressed it became clear that a substantial proportion of the local population was heterozygous for α-thalassemia and it would be important to include this population in the volunteer pool to understand if the heterozygous condition was more resistant to malaria infection by experimental challenge and pose an obstacle that would need to be addressed in future vaccine studies.
In this peri-urban lagoon area near Cotonou, malaria transmission is perennial with the parasite, and the spleen rates are between 40% and 60%, indicating that this is a meso- to hyperendemic area where malaria infection and disease represent a substantial burden for the local population.
In certain cases, these actors have developed substantial support among local populations and have built their own enduring institutions at the expense of de jure sovereign, the state.
Also critical is the availability of water resources and competing demands for land use including food and fiber crops, pasture, timber, and the whole range of forest products which constitute a substantial component of local populations' food security and well-being in terms of health.
Together they would estimate the risk and, if it is substantial, alert and possibly evacuate the local population.
Generally, if Nm < 1, genetic drift will result in substantial local differentiation; if Nm > 1, gene flow between populations is higher and the extent of genetic differentiation is smaller.
First, greater hunting skill combined with increased human population size had the consequence of putting substantial stress on local animal species, many of which underwent local population depletions or extinctions, at which point human hunters switched to different species, often with similar disastrous results on these other animal populations (Kuhn and Stiner 2001).
