Sentence examples for substantial limitations with from inspiring English sources

The review also highlights substantial limitations with this body of research, and more advanced research designs are warranted.

Conventional radionuclide perfusion scintigraphy has been used to assess these abnormalities, but it has substantial limitations with respect to spatial and temporal resolution.

Although the rationale for the study was robust, there were substantial limitations with the study design chosen to answer the question.

This study provides a compelling demonstration that, in spite of substantial sequence length, there are significant limitations with single-locus phylogenetics.

In summary, endoscopy shows highly diagnostic performance in gastric GIST but has substantial limitations for tumors with extrinsic growth.

Additionally, pharmacologic therapy with catecholamines has substantial limitations because these are associated with Ca2+ overload, elevated myocardial oxygen consumption, arrhythmogenesis and regional hypoperfusion leading to organ damage [ 8- 10].

We, however, expect that regardless of the choice of imputation method this remained a sparse dataset with substantial limitations which should be acknowledged and carefully considered when applying this model for future simulation purposes.

In addition to this, although with substantial limitations related to the intrinsic design of the study, more recently a retrospective analysis of a large T1D subjects' database from a national registry on continuous subcutaneous insulin infusion pointed to a higher prevalence of CVD in patients with a history of repeated episodes of hypoglycemia (4).

Perhaps the most substantial limitation associated with MIS is the loss of haptic feedback; this deficit is at its most extreme in robot-assisted surgery, where at present such feedback is lost entirely [ 2].

I was afraid of a shortened life with possible substantial limitations.

Pharmacological therapy with catecholamines presents substantial limitations [ 35, 36], as the decreased myofilament Ca2+ sensitivity during rewarming significantly diminishes β-adrenoceptor effects.