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In return for "substantial limitations which have materially slowed down the Iranian nuclear program," the six powers that negotiated the J.C.P.O.A. afforded sanctions relief.
We, however, expect that regardless of the choice of imputation method this remained a sparse dataset with substantial limitations which should be acknowledged and carefully considered when applying this model for future simulation purposes.
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Traditionally, QT interval is examined in registration trials and postmarketing surveillance, both of which have substantial limitations.
24 25 26 Although previous studies attempted to adjust for comorbidity, this adjustment has often had substantial limitations, the most important of which is reliance on administrative data that may have low sensitivity for the presence of comorbid illness.
Exclusion criteria were as follows: musculoskeletal and neurological disorders that limit physical function, any planned further joint surgery within 12 months and substantial pain or functional limitation which made the patients unable to perform the study procedures.
To define phenotypes in a high-throughput fashion, we used groupings of ICD9 billing codes, which are known to have substantial limitations relative to both sensitivity and specificity of given disease.
However, they also contain substantial limitations: first, as presented here they only apply to those frames which contain a speaking character, and second, they are limited to the visual modality.
This method has substantial limitations since the manufacturing capacity is restricted by the availability of eggs, which may be insufficient to meet the urgent requirements for vaccine during a pandemic [1], [2].
Substantial limitations regarding the "simple" measurement of educational aspirations and the lack of (control) variables which are important to further explain educational aspirations must be noted.
I was afraid of a shortened life with possible substantial limitations.
However, this meta-analysis suffered from substantial limitations.
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