Sentence examples for substantial limitations to from inspiring English sources

There are substantial limitations to the existing research.

This study found that there are substantial limitations to the data available on hypertension and its risk factors.

In addition to the limitations to the survey data for modelling the risk of hypertension, there were substantial limitations to the data available to describe the distribution of risk in subnational populations.

The results are promising and do not indicate any substantial limitation to the deployment of composite fuel.

However, one substantial limitation to this technique is that it takes more than a year for the recipient salmonid gonads to become functionally mature and produce fertile sperm [4], [5], [6].

Although TRAIL is a potent apoptotic trigger in many cancer cells, resistance to TRAIL, either intrinsic or acquired, currently represents a substantial limitation to therapy [ 33].

These results reveal a substantial limitation to the suitability of performing large randomized controlled trials on the efficacy of homeopathy in such a primary care setting.

Finally, given that the need to activate these facilities is extremely rare, the expense of building and maintaining a stand-alone unit poses a substantial limitation to this approach.

While the intracerebroventricular administration of trophic factors has influenced the pathology of neurodegenerative disorders [ 24, 2], the rapid clearance of CSF into the venous circulation has been recognized as a substantial limitation to the pharmakokinetics of this drug delivery route [ 4, 25].

To define phenotypes in a high-throughput fashion, we used groupings of ICD9 billing codes, which are known to have substantial limitations relative to both sensitivity and specificity of given disease.

In addition to this, although with substantial limitations related to the intrinsic design of the study, more recently a retrospective analysis of a large T1D subjects' database from a national registry on continuous subcutaneous insulin infusion pointed to a higher prevalence of CVD in patients with a history of repeated episodes of hypoglycemia (4).