Although there are numerous examples of antioxidant action of plasmalogen in cell cultures and in experimental animals, this hypothesis is far from being satisfactorily proven due to substantial limitations of such studies.
Although meta-analysis of the clinical correlates of anxiety disorder comorbidity in bipolar disorder patients was beyond the scope of this paper, and as pointed out by the authors, may have substantial feasibility limitations; such information could importantly inform clinical efforts to mitigate the adverse effects of concurrent anxiety disorders in patients with bipolar disorder.
A study found that after one year, 52%% of subjects who had received TKR surgeries continued to have substantial limitations during activities such as kneeling, squatting, turning and cutting, carrying loads, tennis, dancing, gardening, and sexual activity, in contrast to only 22%% of matched controls [ 10].
But these studies had "substantial limitations," says psychiatrist Richard Shelton of Vanderbilt University in Nashville, Tennessee, such as small sample sizes or unreliable methods for rating depression.
Current monitoring techniques, such as MUGA (multigated acquisition scan) or echocardiography, have substantial limitations and detect LV dysfunction only after it had occurred.
However, such facility-based studies, while providing valuable information, have substantial limitations and may have underestimated the impact of cysticercosis as a cause of death.
However, such facility-based studies, although providing valuable information, have substantial limitations and may underestimate cysticercosis as a cause of death.
FM symptoms, such as pain, fatigue, and sleep disturbance, can lead to substantial limitations in physical functioning and activities of daily living (ADL), 19 together with lost productivity through higher absenteeism and presenteeism, unemployment, and disability, leading to significant costs.
Although this study had limitations such as small sample size and retrospective design that could have caused substantial biases, it appears that tumour heterogeneity allowed a reasonable level of disease control.
Current pharmacovigilance systems still have substantial limitations, however.
