Proponents of the rule argue that there still are substantial limits on who can invest in these private offerings.
But the prospects of the currency surviving beyond 2015 and 2020 depend upon fundamental reforms of European governance, involving substantial limits on national sovereignty, for which there is little or no public support.
Robert J. Blendon of the Harvard School of Public Health said at one session that research over more than 50 years showed that "during periods of crisis, when security against serious foreign or domestic threats becomes more important, the public will support substantial limits on civil liberties".
Although panel officials said the pact imposed substantial limits on access, it still appeared to establish a precedent for outside access to some of the most highly classified intelligence reports in the executive branch, a precedent that the White House had not been eager to set.
When post-weaning mortalities are added, the loss of potential replacement heifers in pastoral herds would be substantial, limiting the supply of breeding stock to peri-urban herds.
However, LTFU by six months was substantial, limiting our ability to determine HIV-free survival at 18 months.
Imputation of 47% of cotinine concentrations placed substantial limits on linear analyses compared to the Scottish study, in which only a quarter of cases were imputed.
However, the stochastic behaviour of the wind and the important fluctuations of daily and seasonal electricity load pose a substantial penetration limit for the contribution of wind energy in the corresponding load demand.
If these changes are substantial, the limit for what average WTP in this study can finance is soon reached.
However, the radiation dose delivered and the substantial costs limit its widespread application as a screening procedure [ 13].
