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The response rate of 43% with a median duration of response of 8 months observed in our study is in line with the results reported in the other studies with cisplatin and paclitaxel however with substantial less toxicity.
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Equally important, isradipine was substantially less toxic at higher doses than the other DHPs: at concentrations up to 100 μM, isradipine continued to protect against Aβ-associated toxicity without causing a substantial increase in cell death (Anekonda et al., 2011) (and data not shown).
The positive transformants accumulated less ATR and showed less toxicity.
Understanding the principle behind toxicity will assist in the preparation of materials with less toxicity.
Subsequent toxicity study on human peripheral blood mononuclear cells (PBMC) showed that compound 8 exhibited less toxicity than 5-FU.
"It's the planet--less erosion, less toxicity, less greenhouse gas emissions.
The DMSO was chosen due its less toxicity than ethanol.
Additionally, patients treated with T-DM1 experienced less toxicity.
The conjugate showed more stability less toxicity, and increased bioavailability.
Less toxicity was observed with the paclitaxel plus carboplatin regimen.
Exposure to certain chemicals carries the risk of substantial systemic toxicity and even mortality.
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