The phrase "substantial large" is grammatically correct and can be used in written English. It is typically used to describe something that is significantly or noticeably large in size or quantity. Example: The CEO announced a substantial large investment into the company's expansion plans.
Similar definitions are given by the Dictionary of the Older Scottish Tongue that covers the period up to the start of the 18th century; later volumes, when it was published as the Dictionary of the Scots Language and covered from 1700 onwards, include substantial, large and big; it further indicates it may be akin to the Old Norse stórr.
This indicates that Ring1b is involved in direct transcriptional regulation of a substantial large fraction of the deregulated genes in these ontologies.
This strategy, by excluding non-informative rare variants from grouping, is expected to improve statistical power when neutral variants comprise a substantial large proportion of the total variants.
The Climate Council gave South Australia the highest score; 40% of its electricity comes from renewables, and it has a 50% renewable energy target for 2025 and a substantial large-scale renewable capacity.
This is definitely an area for future work when we expand from this case study-based experiment to a substantial, large-scale study.
For TNCs with substantial larger specific surface area and more defect sites, the oxidation peaks of AA, DA and UA were separated well and their oxidation currents increased remarkably.
This indicates that S (and to a lesser extent Si) had substantial large-scale spatial structure that kriging was able to exploit.
That way, the possible benefits of this treatment will be available for a substantial larger group of patients.
When we plot the average methylation level for each CpG marker between tissues, the variation was substantial larger.
However, as the magnitude of measurable BMD loss during pregnancy was substantial larger (5-75-7%han the projected least significant change (LSC) that could be measured with the method, we believe that such measurements should be valid.
Case numbers here were relatively small and individual variation was substantial; larger (ideally, multicentre) longitudinal studies are required to establish the true range of cognitive and neuroimaging features associated with C9ORF72-associated FTD and to evaluate candidate biomarkers.
