Sentence examples for substantial knowledge about the from inspiring English sources

Although substantial knowledge about the ubiquitin-tagging systems has already been accumulated, the mechanisms underlying proteasomal substrate degradation, the irreversible and hence critical step for the unidirectional control of cellular pathways, remain largely elusive.

In the second case it represents substantial knowledge about the objective chances.

Although research on smoking cessation in general population smokers has yielded substantial knowledge about the perceived pros and cons of smoking, there is a lack of central focus.

For either strategy, substantial knowledge about the host enzymes involved in proteolytic breakdown of foreign proteins is required [ 10], but genetic and biochemical information on N. benthamiana proteinases is still scarce [ 11].

Due to the level of this understanding, we are now well poised to gain substantial knowledge about how the environment impinges on the genetic networks underlying development (so called Eco-Devo).

The correction of the problems that we identified in the annotations and models contained in the BioModels Database requires substantial knowledge about both the model structure and their applications.

Previous experiments have provided substantial knowledge about TWINKLE involvement in the mtDNA replication process (20– 23), but it has remained unclear whether TWINKLE is the only replicative DNA helicase in mammalian mitochondria and if the synthesis of the nascent D-loop strands also depends on TWINKLE.

CRP still remains the most validated biomarker in this context, although the substantial knowledge about CRP as a predictor of cardiovascular events is being supplemented by studies on emerging markers [ 5].

These are merely a handful of examples of the substantial knowledge about phenotypes of relevance to evolutionary biology that is represented in this study system [ 8].

At present, we have accumulated substantial knowledge about individual neurons and their interactions in the brain.

Until this day, CRP remains the most validated biomarker but substantial knowledge about CRP as a predictor of cardiovascular events is now complemented by studies of new emerging markers such as interleukin 18, matrix metalloproteinase 9, adiponectin and CD40 ligand [ 4].