Sentence examples for substantial it should be from inspiring English sources

Although the financial cost of hypomethylating agents is substantial, it should be weighed against the patient's potential benefits, in terms of improvement in clinical outcomes, quality of life, and transfusion requirements.

Although this progress is substantial, it should be tempered by the realization that it took nearly a century to develop the necessary infrastructure to begin to solve the problem, and that far too many children will be poisoned unnecessarily by lead in the coming years unless additional action is taken.

We conclude that, to a substantial degree, it should be the TC-APC contact that is moving to the RC-MTOC-GA complex, and not this complex to the contact.

If the overlap is not substantial, then it should be in the direction of the null [ 15].

Because the difference in the trends in lifespan variance by age (s x) is visually striking, substantial, and persistent, it should be accounted for in mortality models and in explanations of population health patterns.

The next time the artistic directorship of a substantial theatre comes round, it should be hers for the taking.

The Observer's Susannah Clapp has written: "The next time the artistic directorship of a substantial theatre comes round, it should be hers for the taking".

At the close of her Observer review of The Seagull, Susannah Clapp declared: "The next time the artistic directorship of a substantial theatre comes round, it should be hers for the taking".

While Congress would no doubt consider that price tag substantial, the officials said it should be compared with the cost of fighting this summer's fires, which is expected to exceed $1 billion, and with the risk of leaving Western forests in their current fire-prone condition.

If TfL is not exaggerating its passenger numbers it should be straightforward to make substantial surpluses.

It should be rich, substantial and salty, so you will reach for a glass of wine or beer between bites.