Visual screening appears to be a simple, safe, acceptable and inexpensive approach but there are substantial issues related to test accuracy and repeatability of visual screening, and screening with visual inspection was not found to decrease cervical cancer mortality in a large-scale trial in rural India [ 19].
Her website also lists a variety of substantial issues tangential to science policy concerns, including healthcare, Medicare, paid family and medical leave, and so on.
Consequently, substantial issues related to explaining and profiling clusters are warranted in future research.
Justice DiNoto ruled that the "evidence was sufficient to raise a substantial issue as to whether the stated reason for singling out Nassau and New York City for Article 18 treatment was, and continues to be, rational".
"It means we have a substantial issue likely to result in reversal," she said.
The player, Muhammed Lasege, a 6-foot-11 native of Nigeria, won an injunction against the N.C.A.A. when Judge Geoffrey Morris ruled that Lasege had raised a substantial issue as to whether the N.C.A.A.'s decision on his eligibility was arbitrary.
"Most institutions are having some issues, and the really substantial issue seems to be around contact hours: what they mean and how you collect the information and make it auditable, from the point of view of the reliability, transparency and accessibility".
The latter represents a substantial issue due to the dendrimer's unnatural chemical structure and relatively large size, which prohibit its in vivo degradation and excretion from the body.
It's probably too late to get candidates with a head of steam to start using rhetorical devices that still allow them to control debate while actually taking on the substantial issues they are supposed to be engaging with.
