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These concerns point to substantial issues in the methodology of the social sciences.
Although cervical cancer is a preventable disease, the clinical and economic burdens of cervical cancer are still substantial issues in Indonesia.
The growing prevalence of type 2 diabetes and widening of the gap between better off and worse off individuals become substantial issues in Korea.
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While no one keeps state-by-state numbers on parole backlogs, Mr. Mauer said, "nobody here is aware of that being a substantial issue in other states".
Whatever else the court's 5-to-4 majority achieved, the result removed the breathlessly awaited case of Ricci v. DeStefano as a substantial issue in the imminent Supreme Court confirmation hearing for Judge Sonia Sotomayor.
In Colorado, before requiring a reporter to testify about confidential sources, a court must be convinced that the information is "directly relevant to a substantial issue in the proceedings".
In Colorado, a witness can be compelled to disclose the identity of a source if three criteria are met: if the party seeking the information can prove the information is directly relevant to a substantial issue in the trial; if it cannot be obtained by any other reasonable means; and if the interest of the party seeking the evidence outweighs the interests of the reporter and the general public.
Second, data provenance is another substantial issue in predictive toxicology.
"History would say that we're going to have a substantial issue in one of the first three flights.
The most substantial issue in the training process of each 2 p + q − 1 ANNs for change point estimation purpose is collecting proper training data sets.
The unpredictable side effects of a majority currently used drugs are the substantial issue, in which patients and physicians are forced to deal with.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com