Sentence examples for substantial interruption from inspiring English sources

Mr. McDonald "caused a substantial interruption and delay in the flight," and his actions might require "replacement of the plane's emergency chute," the district attorney's office said.

For patients receiving continuous therapy, emphasis needs to be on ensuring that treatment times are maximized, since prior studies have suggested substantial underestimation of interruptions of treatment [ 30].

Although the sequence requirements for poly-pu/py-rich sequences to form secondary structures are not fully understood [ 52, 53, 56], the structures can tolerate a substantial proportion of interruptions to the homopurine/homopyrimidine motif [ 34, 36, 53], and can also be sensitive to single nucleotide changes [ 38, 39].

While these analyses give us only a limited perspective on the mechanism of recombination, it is notable that the abundant SNPs suggest that each of the characterized events involved exchange of a substantial segment without interruptions (at least 1 kb), rather than restricted local repair.

However this is a relatively recent improvement, with outcomes prior to 2003 significantly lower than this, including substantial rates of treatment interruption and default.

On recovery nights (after such deprivation), when the subject can sleep without interruption, there is a substantial increase in the number of reports of dreaming.

In Canada and Australia, substantial measures, including police checkpoints and interruption of road and rail traffic, did not prevent or appear to delay the spread of infection between Canadian provinces or Australian states (4, 18 ).

The visitors won the toss and elected to bat, setting Ireland a substantial total to chase despite four interruptions caused by rain and hail.

The nodal feathers scattered throughout the primaries and outer secondaries suggest interruptions of molt for substantial periods of time.

One of the newly sequenced genomes, Pumpkin, is a member of Cluster E, a group of five genomes with substantial similarity but with more syntenic interruptions than seen in the Subcluster B1 genomes discussed above.

Nevertheless, therapeutic failure still remains substantial, in particular due to late initiation, interruption or refusal of cART, incomplete adherence to therapy, medication toxicities, antiretroviral drug resistance, hepatitis virus co-infections, consumption of alcohol, illicit drug use, or depression.