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This observation reflects the substantial insufficiency of using HER2 gene amplification or HER2 protein overexpression to predict patient responsiveness to Herceptin.
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This strategy is competitive with a 4-pathway genomic breeding program if the fraction of selected male calves for the artificial insemination program is below 1% and if selection is focused on functionality, thus pointing to substantial insufficiencies caused by low reliabilities of breeding values for cows for such traits in conventional bull dam selection schemes.
In Geelong, there is substantial vitamin D insufficiency and deficiency during winter and spring, and for a large part of that time sun protection is recommended.
I am not sure if this would be the best scenario to start the article, although its issues with renal insufficiency are substantial.
This limb obviously has a substantial degree of arterial insufficiency, and a case could be made in the near future for this patient to undergo amputation, below or above the knee, depending on the location and severity of the arterial insufficiency.
The prevalence of vitamin D deficiency and insufficiency is substantial among adolescents in the U.S.; ~2% of adolescents had concentrations of vitamin D <27 nmol/L, 14% had concentrations <50 nmol/L, and 33% had a concentration ≥75 nmol/L during 2001 2004 (4, 5).
Third, there is a substantial prevalence of thyroid hormone insufficiency in the population of U.S. women, indicating that compensatory processes are already compromised for many individuals.
Caution is advocated when treating patients with moderate hepatic impairment, and ivabradine is contraindicated in patients with severe hepatic insufficiency (as a substantial increase in systemic exposure is predicted) [ 44].
The burden of disease attributable to nutritional insufficiencies has remained substantial in recent decades.
Relative adrenal insufficiency occurs in a substantial proportion of patients following major abdominal surgery.
High-dose interleukin-2 therapy is associated with substantial toxicity including hypotension, oliguria, renal insufficiency, hepatocellular damage, edema, respiratory compromise, fevers, chills, pruritis, diarrhea, myocardial infarction, sepsis, and death.
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