"substantial instability" is a correct and usable phrase in written English.
It refers to a significant level of instability or lack of stability. Example: The country's economy has been facing substantial instability due to the frequent changes in government policies and external factors.
But this ties into a far broader problem; namely, how should central banks counteract dangerous pressures in financial markets without generating substantial instability in the real economy?
Mutational substitution of such Cys residues eliminates reactive buried thiols but cannot be accomplished simultaneously at all 3 positions without also introducing further substantial instability.
The substantial instability of 'capacitance' value during the operation of EDLCs suggests that it can hardly be used as the proportionality constant between energy accumulated by an EDLC and the voltage in the second power.
Proteins that exhibit substantial structural instability are likely passed from the chaperones to proteases.
We also performed elbow synovectomy at advanced stages and this was not followed by substantial joint instability.
Of the 23 (17.4%) complete genome sequences, 4 showed substantial genomic instability directly upstream of the right ITR.
The tumour samples analysed demonstrated substantial genomic instability, with comparisons between subgroups failing to demonstrate any significant difference.
Substantial contextual instability occurred during the intervention period, such as new work programs and several organizational changes with implications for work duties, work content and workload.
In summary, ribonucleotides are highly deleterious to the mammalian cell when left incorporated in the nuclear genome, causing substantial genome instability.
Indications for primary arthroplasty with the EnduRo system included severe varus or valgus osteoarthritis (more than 20°) with substantial ligamentous instability, rheumatoid arthritis with ligament laxity, and posttraumatic and postinfectious gonarthrosis.
Impaired or lost BRCA1 function underlies substantial genome instability including increases in the number of mutations, DNA breakage and chromatid exchanges, increased sensitivity to DNA damage, and defects in cell-cycle checkpoint functions.
