Sentence examples for substantial increase in cost from inspiring English sources

It makes it possible to implement automatic protection mechanisms without a substantial increase in cost.

This would quadruple the number of genotypes without any substantial increase in cost.

Trials have shown that the new treatments increased the rate to 80%to95%95 %, though with a substantial increase in cost.

The present standard of care, direct antiviral agents telaprevir and boceprevir, has offered higher sustained virological response rates but with a substantial increase in cost.

For the first time, companies will be charged for inspections to defray a substantial increase in costs for policing the new inspection regime.

Mr. Kerrey said that the university, which is heavily dependent on tuition revenue, had seen "a substantial decline in revenues and a substantial increase in costs" after Sept. 11, and that he had reined in hiring and other spending as a result.

Fox said: "At the point we say we are leaving the EU, the French can quite rightly turn round and say: 'Stuff you, EU law doesn't apply to the UK any more, you're in France so you stick to French law.' The consequence of this is that chalet operators are going to have a very, very substantial increase in costs.

Because of substantial increase in costs, physicians need to consider the cost-effectiveness of new therapies as well as the clinical issues.

For example, a substantial increase in costs for general veterinary care in horses was found over an 8-year time period using Swedish data.

In the same report, EIA also predicts substantial increases in cost of coal and wind-powered plants.

Networks also face substantial increases in costs because of news coverage of the terrorist attacks.