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"substantial inconsistency" is a correct and usable phrase in written English.
It can be used to describe a significant lack of agreement or coherence in something, such as an argument, theory, or statement. Example: The politician's speech was filled with substantial inconsistencies, causing many to question the validity of his promises.
Exact(11)
Each of these factors may contribute to the substantial inconsistency between RNA-level microarray-based networks and currently defined pathways.
We have revealed substantial inconsistency between the data from different methods, but the extent of these inconsistencies is also partly a result of the narrow definition of inconsistency: a looser (and perhaps more realistic) definition results in fewer inconsistencies (just as a looser definition of adherence results in higher adherence).
Similarly, another substantial inconsistency was observed in one of 12 comparisons of escitalopram and venlafaxine [ 31].
Previous research indicates that there may be substantial inconsistency in self-reports of lifetime abstention.
Besides, we found no significant heterogeneity in our traditional meta-analyses and no substantial inconsistency in our network meta-analyses.
This means that one substantial inconsistency in the estimates is likely to influence the estimates of other migration flows.
Similar(48)
Despite terrific progress in refining educational interventions, the diabetes literature continues to contain substantial inconsistencies in reporting the elements of educational interventions.
Henry Sanchez Milian, 18, and Jose Montano, 17, were ordered released from custody Friday morning after "substantial inconsistencies" emerged in witnesses' accounts of what happened, Montgomery County State's Attorney John McCarthy said at a press conference following a court hearing in the case.
Our results also highlighted substantial inconsistencies between individual countries for each vaccine.
In addition to substantial inconsistencies among existing gold standards, variation in biological specificity within each standard has also impaired previous evaluation methods.
We detected substantial inconsistencies between the number of FBO employees reported by district authorities and the situation assessed on the ground.
Related(20)
considerable inconsistency
serious inconsistency
notable inconsistency
fundamental inconsistency
large inconsistency
major inconsistency
huge inconsistency
substantial incongruity
tremendous inconsistency
important inconsistency
massive inconsistency
remarkable inconsistency
great inconsistency
material inconsistency
substantial inconsistencies
substantial grievance
substantial funding
substantial book
substantial neglect
substantial effectiveness
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com