These depression symptoms can become chronic or recurrent and lead to substantial physical inactivity and poor family functions [ 8].
In order to harvest the maximum weight of cashmere, the optimal time for a single shearing of cashmere goats would be at the end of the winter season before follicle inactivity becomes substantial or before onset of shedding.
As an underlying cause of mortality and morbidity with an associated substantial economic burden, physical inactivity is a major international health concern [ 1– 4].
Among women, high levels of strain at work can have even more substantial effects on physical inactivity if combined with the demands of family responsibilities [ 19, 43].
Unfortunately, it is also apparent that in sedentary middle-aged men and women, short periods of physical inactivity lead to significant weight gain, substantial increases in VAT, and further metabolic deterioration.
In a previous multilevel analysis of population survey data from Caerphilly county borough, one of the 22 local government unitary authorities in Wales, UK, we found evidence for substantial contextual effects of ward-level economic inactivity on individual mental health [ 30].
New surveillance officers can look forward to "sitting for substantial periods of time" and "long spells of inactivity", to say nothing of the "limited promotion opportunities".
Even a 10% reduction in the prevalence of physical inactivity, for example, could lead to substantial reductions in direct health-care expenditures [ 2].
A compelling piece of evidence suggests that physical inactivity is a strong determinant of childhood overweight and obesity which increases the risk of many chronic diseases in later life and that modest increases in physical activity have the potential to produce substantial health benefits (Roux et al., 2008).
Despite all known benefits, large groups of people are insufficiently active and inactivity is an important public health problem accounting for substantial healthcare costs [ 10– 10].
According to Booth and coworkers [ 7], physical inactivity is the key environmental factor contributing to the substantial increase in the incidence of chronic conditions in the latter part of the 20th century.
