From our experimental evaluation we conclude that the addition of only one binding-relevant sub-structural feature of a known ligand can substantial improve the enrichment factors in the virtual screening.
Neither a change in Italian command nor the arrival of substantial reinforcements improved the position of the Italian army.
China has in fact made substantial progress improving many social and legal protections over the past 20 years, Chinese and Western rights experts say.
It is thought that Michael Gove, the education secretary, regarded the free school meals proposal as political showmanship designed to win Clegg votes at the election, but unlikely to do anything substantial to improve schooling.
I hate the idea, common on the Guardian blogs, that "bad" music (usually manufactured pop) brainwashes or cheapens people, as if music should have to be substantial or improving, like a Victorian novel.
It is thought that Gove regarded the free school meals proposal as political showmanship designed to win Clegg votes at the election, but unlikely to do anything substantial to improve schooling.
In view of this, the above contribution does not add anything substantial in improving our existing knowledge of climate-tectonic interaction in landform evolution.
Reviewers provided substantial feedback that improved the manuscript.
Ultimately, 85 out of 120 problem instances are further improved with substantial margins.
Current empiric chemotherapy can offer a minority of patients with unfavorable prognostic factors substantial clinical benefit and improved survival.
