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Evidence suggests that a majority of patients even in early stages of the disease experience substantial impairments potentially resulting in diminished therapy adherence as well as impaired quality of life.
Importantly, these microenvironmental alterations were associated with substantial impairments in ductal expansion and mammary gland development.
Language comprehensionat the single word level (i.e. in picture-word matching task) can be in mildly cognitively impaired patientspreserved, so clinically the language processes seem to be normal, but more comprehensivelanguage testing (i.e. at sentence level) can reveal substantial impairments even inpatients with mild dementia.
A number of studies have demonstrated that Huntington's Disease, a disorder that causes a degeneration of the neostriatum, is associated with substantial impairments in timing [14]; this abnormality is observed even in subjects with this disorder who are in many other respects pre-symptomatic (e.g., [15]).
In addition, we found substantial impairments in other tracts, such as the stria terminalis.
Consequently, patients with chronic pancreatitis experience substantial impairments in health-related quality of life [ 3].
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Symptomatic patients might not show impaired range of motion while symptomatic patients might present substantial impairment of lumbar movements.
These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment".
The law says that if parents have "substantial impairment of judgment," then there is a presumption of neglect, but it does not refer to quantities of drugs.
In the absence of such immunity, granted by law or obtained privately from adjacent landowners, the owners, operators, and users of airports are basically liable, in much the same way as other occupiers of land, for any substantial impairment of the use or enjoyment of neighbouring lands.
It is also associated with substantial impairment of patient quality of life (QOL).
More suggestions(15)
fundamental impairments
substantial inadequacies
important impairments
remarkable impairments
considerable impairments
substantial disabilities
substantial encroachments
substantial complications
substantial disorders
substantial damages
substantial restraints
substantial deficiencies
notable impairments
noticeable impairments
substantial alterations
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com