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In this case, under conditions of further immunological stimulation by CL4 cells, transfected with a human cDNA, substantial immune reactions occurred.
A combination of activities against sporozoites, infected liver cells, merozoites and infected red blood cells may be required to achieve substantial immune protection [9].
This approach eliminates far more sequence for each HCV genome than is actually under immune selection in a given patient, but its advantage is that the remaining sequences are very unlikely to be under substantial immune selection.
By contrast, we have observed substantial immune responses towards mature amyloid fibrils in the control group and subsiding, but still pronounced, reactivity in early PD and to a lesser extend in late PD as measured by Western blotting (Figure 5A).
The summary of Western blot analysis is presented in the box-plots in Figure 5A for each examined group, demonstrating substantial immune responses towards α-synuclein amyloid fibrils in all of them.
Based on these results, we conclude that SCI is followed by compromised BTB integrity by as early as 72 hours post-injury in rats and is accompanied by a substantial immune response within the testis.
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Recent evidence demonstrating that γδ T cells rather than FoxP3+CD4+T cells contain the dominant regulatory T cell subset in cattle [ 38] raises the intriguing possibility that the requirement for a substantial immune-regulatory T cell population may have been a factor leading to the expansion of TRDV1+ γδ T cells in cattle and other artiodactyls.
This effect may be attributable to the multiple infusion schedule, which may lead to a substantial humoral immune response against the CAR with murine SS1 scFv.
Investigators believed that this finding provided one potential mechanism for the loss of CAR-T cells observed in other trials and concluded that Cy/Flu could minimize the substantial cellular immune response against CAR.
Except for APMV-5, each APMV induced a substantial humoral immune response.
MoPn infected mice displayed a very substantial protective immune response even in the absence of CD4+ T cells.
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