Sentence examples for substantial hypothesis that from inspiring English sources

It is a substantial hypothesis that the reduced mean-D in our patients mirrors the cerebral microvascular changes associated with CADASIL.

This is truly a hypothesis that is extremely subjective.

There is an alternative hypothesis that makes far more sense.

Our findings also support a new hypothesis that substantial chromosome rearrangements have occurred between families.

Our study provides no substantial support for the hypothesis that the polymorphic variants TGFBR1*6A or Int7G24A contribute to familial CRC risk.

This confirmed that ira2Δ HQ sensitivity is not due to a specific property of Ira2p and provides substantial support for our hypothesis that the level of active Ras signaling modulates the toxicity of HQ.

However, substantial evidence supports the hypothesis that sarcoidosis stems from interactions among genetic and environmental factors, which would account for the significant heterogeneity in this disease across different ethnic groups.

Our results provide substantial evidence for the hypothesis that Cdk inhibitor P276-00 enhances doxorubicin-induced killing of NSCLC cells in vitro as well as in vivo without any significant toxicity especially in p53 positive tumors.

There is substantial evidence supporting the hypothesis that selective resistance to insulin-stimulated (muscle) glucose disposal and the consequential compensatory hyperinsulinemia trigger a variety of metabolic effects, likely resulting in accelerated oxidative stress and aging [ 39, 77].

Further, this demonstrates that the composite covariate of caveolin-1 and activated AKT serves as a linked molecular signature to identify localised tumours that have an increased propensity to metastasise and provides substantial support for a hypothesis that caveolin-1 acts synergistically with the AKT/mTOR pathway in driving disease progression in RCC.

Substantial evidence supports the hypothesis that fibrillar Aβ is conformationally distinct from monomeric Aβ but the investigation into the specific structural transition states of Aβ along the pathway to mature fibrils has been hampered by the inability to arrest the transient Aβ oligomers in stable, intermediate conformations.