In addition, the terminal dynamic rheological data showed strong dependence on the clay content, indicating substantial hindrance to chain relaxation by tethering clay particles.
Our nanofilter enables the precise modification of the nanoscale pore surfaces of the formed silica NTs with organic moieties, such as trimethylchlorosilane, leading to the efficient filtration of high concentrations of proteins (retentate ≥ 10−4 mol dm−3) without substantial kinetic hindrance.
When a valine residue side chain was modelled on to His of the G89P crystal structure, the separation between the valine Cγ2 atom and the Cδ1 atom of Tyr was reduced to 2.9 Å, suggestive of a substantial steric hindrance to such a conformational transition.
The only real hindrance is confidence.
So, it's been a real hindrance.
That, of course, brings us right back to square one: Defining an "undue burden" as an "undue hindrance" (or a "substantial obstacle") hardly "clarifies" the test.
The Congress finds that personal injuries and illnesses arising out of work situations impose a substantial burden upon, and are a hindrance to, interstate commerce in terms of lost production, wage loss, medical expenses, and disability compensation payments.
The states will argue that the law should be read such that any hindrance to business must be "serious" or "substantial".
The future will demonstrate, in my judgment, how wrong it is for this court to attempt to become a continuing umpire or a standing Master to whom the parties must go at intervals for leave to do what, in their sovereign right, they should be able to do without let or hindrance, provided only that they work no substantial damage to their neighbors.
In order to detect a possible substantial change in the patient's condition, the shoulder hindrance scale was used.
However, PEGylation results in a substantial loss of the bioactivity of proteins due to the steric hindrance of polyethylene glycol (PEG).
