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The substantial higher concentrations of the studied heavy metals and PAHs implied potential risk of toxicity on human health when this medicinal fern was harvested from polluted sites.
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Although 200 μM had little effect, but cytotoxicity was substantial at higher concentrations.
Low amounts of added enzyme (3 or 5 mU/ml) had little effect, but cytotoxicity was substantial at higher concentrations.
According to the Intergovernmental Panel on Climate Change (IPCC), there is substantial evidence that higher concentrations of CO2 and other greenhouse gases have increased the mean temperature of the Earth since 1950.
For higher concentrations, a substantial increase in the GMR ratio is observed.
In contrast, even low concentrations of bortezomib (5 nM) substantially shifted the populations of surviving cells and higher concentrations (7.5 nM and 10 nM) elicited even more substantial shifts.
Whereas mice showed a moderate increase in foot withdrawal latency at 10 nM and a greater, more prolonged increase at higher concentrations (Fig. 3A), APV had no substantial effect at any concentration in naked mole-rats (Fig. 3B).
Therefore, PM effects might be substantial at low to middle range doses and taper off at higher concentrations.
Higher concentrations of coarse PM measured indoors were associated with substantial increases in asthma symptoms in both the bivariate and the multivariate models (Tables 3, 4).
No substantial effects on cell viability were observed at these concentrations of lactic acid, although higher concentrations (up to 30 mM) did induce cell death (Fig. 1C, Fig. 1D).
Due to the presence of much higher concentrations of other immunoglobulin isotypes, the assessment of specific serum IgE antibody poses substantial technical challenges.
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