Microscopic examination of brain tissue from mice infected with the Sterne strain showed thickening of the meninges, an influx of inflammatory cells and substantial hemorrhaging (Fig. 7D F).
Although decreased morbidity due to aggressive use of plasma and platelets has been reported [ 318, 349, 354], routine early prophylactic platelet transfusion as part of a massive transfusion protocol appears unjustified at this time We suggest administration of platelets in patients with substantial bleeding or intracranial hemorrhage who have been treated with antiplatelet agents.
We found little evidence to support either of these sites as a substantial source of hemorrhage.
Though we did observe a few areas of hemosiderin-positive staining in those animals with the largest number of vascular events, we did not see substantial numbers of hemorrhages in the db/AD animals.
Similarly, suboptimal inhibition of Pin1 leads to severe rejection pathology with substantial cellular infiltration and hemorrhage (Figure 6).
Evaluation of lung pathology at day 6 postinfection showed marked edema, pneumonia, and hemorrhage with substantial inflammation in the AmBisome-treated infected mice (either WT or Ifitm3−/−) as compared to the WT mice not exposed to AmBisome.
In this study steroid treatment was associated with a substantial increase in intraventricular hemorrhage, a decrease in scores on the Griffiths scales of motor development from 104 to 93, and a possible increase in gross neurological abnormalities.
The H&E staining revealed substantial morphological changes, including hemorrhage, edema, alveolar collapse, and infiltration of inflammatory leukocytes in the lung tissues of the vehicle-treated mice, compared to the sham mice (Fig. 3a).
In both hemothorax cases, the hemorrhage was not substantial, and the patients were observed without further intervention.
