'substantial heart' is not correct or usable in written English as it is not a correct phrase.
However, you could use the two words separately in a sentence such as, He had a substantial amount of courage in his heart.
By the time Vioxx, which was approved by the Food and Drug Administration in 1999, was pulled off the market in 2004 because evidence showed that it posed a substantial heart risk, about 25 million Americans had taken the drug.
This brief deterioration in gas exchange did not appear to be ultimately problematic, and there were no substantial heart rate or blood pressure changes as CPAP was established.
However, one of the difficulties in using spectral analysis to study the relation between cerebral profusion and the arterial pulse is that during the period of data collection, there is, in general, substantial heart rate variability.
Exclusion criteria were the following: no laboratory confirmation, age <18 years or >60 years, preexisting substantial heart or lung disease or concurrent medication affecting heart rate, e.g., β-blockers, β-agonists, calcium channel blockers, or xanthine derivatives.
The Fridericia method for correcting the QT interval for heart rate is often not fully adequate in the setting of substantial heart rate increases and commonly results in overcorrection and inflated QTcF increases, independent of repolarization 34.
Mosaic trisomies of chromosome 17 are associated with substantial heart defects, including truncus arteriosus and Tetralogy of Fallot, as well as speech delay (37), consistent with phenotypes in the proband, and considered the likely cause of disorder.
Use of acute hospital resources was substantial, with heart failure patients occupying almost 200,000 bed-days per year in NSW over the five year study period.
Substantial resting heart rate elevation is associated with increased CV mortality, and drugs that prolong cardiac repolarisation carry a risk of provoking adverse CV events [ 109, 110].
However, the impact on acute care hospital beds was substantial, with heart failure patients occupying almost 200,000 bed-days per year in NSW over the five year study period.
The agency decided that existing patients could continue taking the medicine but that new patients could get it only if they and their doctors attest that they have tried every other diabetes medicine and have been informed of the drug's substantial risks of heart attacks, strokes and heart failure.
"If we exclude this group, then potentially a substantial number of heart failure patients would not be eligible to receive this therapy.
