Sentence examples for substantial functional role from inspiring English sources

This suggests that these latter regions play a substantial functional role in the selective advantage of tumor cells.

Not surprisingly, none of these crippled RNase P RNAs gave rise to RNase P activity without protein in vitro, and it is assumed that the protein moiety of the enzyme has a more substantial, compensatory functional role in the holoenzyme.

After gene duplication, two duplicates can undergo substantial functional divergence, and it plays a major role in the evolution of new functions [40].

Comparative genomic hybridization analyses of 41 strains indicate that substantial heterogeneity exists with respect to the genes comprising functional role categories.

This study reported a subset of 17 genes showing differential methylation that included a substantial number that has been demonstrated to play a functional role in cancer-related processes.

We show neuroligins and neurexins comprise a highly conserved molecular system with likely similar functional roles in insects as vertebrates, and with scope in the honeybee to generate substantial functional diversity through alternative splicing.

Thus, a possible role for the linker loop could be to stabilize the apo conformation of the P-loop, in line with recent studies suggesting a functional role for the linker (truncating this acidic linker can have a substantial effect on the activity of isolated NS3Hel domains; Li et al., 1999; Wu et al., 2005; Mastrangelo et al., 2007b).

However, a substantial number of GABAARs with a typically 'synaptic' subunit composition also exist extrasynaptically, although the functional role of such receptors remains to be established (Kasugai et al., 2010).

But the theme has a functional role as well.

I think the chief diversity officer role was initially considered to be very much an organisational development and HR functional role.

Lycan (1996) appeals to functional role.