Sentence examples for substantial functional changes from inspiring English sources

In addition, substantial functional changes likely occurred through gains or losses of functional domains.

Such variants could, perhaps, be expected to result in substantial functional changes.

Relatively minor degrees of genetic variation can lead to substantial structural and functional changes – as evidenced by the modest changes that distinguish primate species or that can produce profound disease phenotypes in Mendelian-related traits.

The organization of the somatotopic maps in the primary somatosensory cortex and thalamus are known to undergo substantial structural and functional changes after amputation (Ramachandran and Hirstein, 1998; Flor et al., 2006).

One question that arises immediately is how to distinguish "substantial" and more "subtle" functional changes at the molecular level?

While substantial research has charted how structural and functional changes in these language-related areas contribute to reading improvement during development, the role of cortical sensorimotor representations in this process has not yet been explored.

In addition to the need for larger validation studies to confirm the observed associations, substantial additional research is needed to understand the functional impact of the various candidate polymorphisms on protein function and expression levels and how these functional changes contribute to alterations in ARDS outcomes.

Third, we hypothesize that substantial exon/intron structural changes that occur in tetraspanins are associated with major functional changes in these proteins.

We hypothesized that the morphological and functional changes that occur during cancer progression would lead to substantial changes in the cancer transcriptome, including a reduction in specialization, when compared to that of analogous normal tissues.

These oxidative modifications lead to functional changes in various types of proteins (enzymatic and structural), which can have substantial physiological impact.

Though there was substantial functional disability in the patients as evidenced by HAQ-DI baseline scores, there was no significant change in HAQ-DI between groups from baseline to 26 weeks, which was similar to other trials.