Plant ABC transporters fall into several subfamilies with varied (and often uncharacterized) functions but with a substantial functional redundancy of the family members within a single organism [ 113].
After gene duplication, two duplicates can undergo substantial functional divergence, and it plays a major role in the evolution of new functions [40].
Headaches rank third among illness-related causes of school absenteeism and result in substantial functional impairment among pediatric patients [16].
At a minimum of 1 year follow-up, they noted substantial functional improvement in all their patients.
Recently, environmental signals have been shown to epigenetically influence canonical ILC differentiation pathways, generating substantial functional plasticity.
Migraine is a prevalent neurologic disease characterized by severe recurrent headache pain [1] and is associated with substantial functional and quality of life impairments [2].
This study highlights how the burden of migraine extends beyond the patients, with substantial functional and emotional impacts of the disease on caregivers.
Hoarding Disorder (HD) is a burdensome and disabling mental health condition, which is associated with substantial functional disability and represents a major public health issue.
Substantial functional diversity of fallow patches in simple landscapes was due to high abundance of functional species, while that of river margins stemmed from presence of unique species.
Moreover, its expression is not stabilized by positive feedback loops but rather influenced by environmental cues, allowing for substantial functional plasticity.
Due to substantial functional redundancy of these enzymes, lack of inhibition of even a single plasmepsin can defeat efforts in creating effective antiparasitic agents.
