Sentence examples for substantial for the development from inspiring English sources

They conclude, that these circumstances are substantial for the development of osteochondral lesions with all their follow up [ 10].

In its response, the company argued that it assumed substantial risk for the development and manufacturing of the vaccine and that the price "was based on independent negotiations with two agencies of the US government", both of which "determined the price to be fair and justified".

This provides substantial motivation for the development of strategies to visualize the parts of a molecule contributing to a similarity value or model prediction.

Consequently, tyrosine kinases have been a substantial focus for the development of targeted therapeutics.

YCC and RS made substantial contributions for the development and implementation of ComBlast and for the analyzing the data.

This study provides substantial impetus for the development of a systematic consumer engagement framework for healthcare priority setting.

Control of this step offers a substantial opportunity for the development of novel cancer therapeutics that traverse the endosomal/lysosomal compartment of tumor cells.

Targeting these key players may hold substantial promise for the development of novel therapies for age-related pathologies with aberrant IGF-1 signalling such as type 2 diabetes, skin atrophy, osteoporosis, impaired wound healing, neurodegeneration, and cancer.

We think that the successful treatment of DN with MSCs demonstrated here holds a substantial promise for the development of novel MSC-based interventions that can prevent the progression of DN.

Unemployment and poverty may be substantial risk factors for the development of depressive symptoms.

In conclusion, maternal occupational exposures during pregnancy do not seem to be a substantial risk factor for the development of asthma in 7-year-old children.